uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Arterioles of the lenticular nucleus in CADASIL
Show others and affiliations
2006 (English)In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 37, no 9, 2242-2247 p.Article in journal (Refereed) Published
Abstract [en]

Background and Purpose-In cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) the arteriopathy leads to recurrent infarcts in cerebral white matter (WM) and deep gray matter (GM), whereas cortex is spared. To assess the pathogenesis of deep GM infarcts, we analyzed structural changes in arterioles of the lenticular nucleus (LN) in 6 CADASIL patients.

Methods-Five elderly and one 32-year-old deceased CADASIL patients were studied. Seven elderly and 4 young deceased persons without cerebrovascular diseases served as controls. In addition to immunohistochemical analysis the external and luminal diameters of arterioles in the LN, cerebral cortex and WM were measured. The thickness of arteriolar wall and sclerotic index were calculated.

Results-In CADASIL patients, LN arterioles were immunoreactive for the extracellular domain of Notch3 and collagen 1, whereas a-smooth muscle actin staining was irregular or negative. No major leakage of plasma fibrinogen or fibronectin was observed. Although in patients the walls of LN arterioles were significantly thicker than in controls, definite stenosis was not observed. Arteriolar lumina in the LN were not only significantly larger than in the WM, where most lacunar infarcts in CADASIL occur, but also larger than in cortical GM, where infarcts virtually never exist.

Conclusions-Fibrotic thickening of the arteriolar walls without consequent stenosis occurs in the LN of CADASIL patients. The pathogenesis of lacunar infarcts in the WM and LN seem to be different, stenosis in the former and probably hemodynamic disturbances in the latter.

Place, publisher, year, edition, pages
2006. Vol. 37, no 9, 2242-2247 p.
Keyword [en]
CADASIL, cerebral arteries, fibrosis, lenticular nucleus, stenosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-10691DOI: 10.1161/01.STR.0000236838.84150.c2ISI: 000241715900022PubMedID: 16873707OAI: oai:DiVA.org:uu-10691DiVA: diva2:38459
Available from: 2007-04-19 Created: 2007-04-19 Last updated: 2011-05-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kalimo, Hannu
By organisation
Department of Genetics and Pathology
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 171 hits
ReferencesLink to record
Permanent link

Direct link