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Skeletal Muscle HSP Expression in Response to Immobilization and Remobilization
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2007 (English)In: International Journal of Sports Medicine, ISSN 0172-4622, Vol. 28, no 4, 281-286 p.Article in journal (Refereed) Published
Abstract [en]

Heat shock proteins play an important regulatory role in the cellular defence. Oxidative stress is one of the factors inducing heat shock protein expression. This study tested the effects of 4 weeks of immobilization and subsequent remobilization on heat shock protein expression and oxidative stress in the lateral gastrocnemius and plantaris muscles of the rat. Active mobilization or free mobilization protocols were used for remobilization. In active mobilization, strenuous uphill treadmill running, twice a day, was started immediately after the immobilization and lasted for six days. Rats in the free mobilization group moved freely in their cages immediately after the immobilization. Expression of heat shock proteins was upregulated during the recovery from immobilization, especially in the lateral gastrocnemius muscle in the active mobilization group. However, markers of oxidative stress, such as protein carbonyls and 4-hydroxynonenal protein adducts, or activities of the antioxidant enzymes glutathione peroxidase and glutathione reductase, did not change after the immobilization and subsequent recovery. In summary, following immobilization, both intensive and spontaneous exercise upregulated the heat shock protein expressions in the lateral gastrocnemius muscle and partly in the plantaris muscle, which may contribute to the recovery from immobilization atrophy.

Place, publisher, year, edition, pages
2007. Vol. 28, no 4, 281-286 p.
Keyword [en]
Mobilization, oxidative stress, heat shock proteins
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-10694DOI: 10.1055/s-2006-924350PubMedID: 17024631OAI: oai:DiVA.org:uu-10694DiVA: diva2:38462
Available from: 2007-04-19 Created: 2007-04-19 Last updated: 2010-04-09Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17024631&dopt=Citation

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Kalimo, H
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