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Deep brain stimulation in the treatment of depression
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
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2011 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 123, no 1, 4-11 p.Article, review/survey (Refereed) Published
Abstract [en]

Objective: To present the technique of deep brain stimulation (DBS) and to evaluate the studies conducted on DBS in the treatment of therapy-refractory major depressive disorder (MDD). Method: A review of the literature on DBS in the treatment of MDD was conducted. Results: The results of DBS in MDD have been presented in 2 case reports and 3 studies of 47 patients operated upon in 5 different target areas. Positive effects have been presented in all studies and side effects have been minor. DBS in the nucleus accumbens resulted in a mean reduction of Hamilton depression rating scale (HDRS) of 36% after 1 year and 30% of the 10 patients achieved remission. DBS in the internal capsule/ventral striatum resulted in a reduction of 44% after 1 year, and at the last evaluation after in mean 2 years, 40% of the 15 patients were in remission. The 20 patients with subcallosal cingulated gyrus DBS had a reduction of HDRS of 52% after 1 year, and 35% were within 1 point from remission or in remission. Conclusion: DBS is a promising treatment for therapy-refractory MDD. The published experience is, however, limited, and the method is at present an experimental therapy.

Place, publisher, year, edition, pages
2011. Vol. 123, no 1, 4-11 p.
Keyword [en]
deep brain stimulation, depression, stereotaxy
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URN: urn:nbn:se:uu:diva-141106DOI: 10.1111/j.1600-0447.2010.01625.xISI: 000285099300002PubMedID: 20961293OAI: oai:DiVA.org:uu-141106DiVA: diva2:385009
Available from: 2011-01-11 Created: 2011-01-11 Last updated: 2015-02-25Bibliographically approved

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