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Purinergic signalling in pancreatic islet endothelial cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2010 (English)In: Extracellular ATP and adenosine as regulators of endothelial cell function: implications for health and diseas / [ed] E. Gerasimovskaya, E. Kaczmarek, Springer , 2010, 215-231 p.Chapter in book (Other academic)
Abstract [en]

Both the microvascular endothelium and the endocrine cells in the pancreatic islet can release and react upon ATP. In support for the idea that intermittently released ATP, related to exocytosis of insulin secretory granules, affects the secretory activity of the capillary endothelium, we have demonstrated that isolated endothelial cells respond to activation of P2Y2 receptors with pronounced and extended rises of [Ca2+]i. The presence of such ATP effect is consistent with reports that β-cells regulate the blood flow within islets, where adenosine is a key mediator, and that the endothelial cell produce pro-angiogenic and angiostatic factors. In β-cells down-regulation of P2Y1 receptors results in disappearance of the transients of [Ca2+]i supposed to entrain these cells into a common rhythm. Since the islet endothelial cells respond to activation of P2Y2 receptors with extended elevation of [Ca2+]i, it is likely that the accompanying release of ATP is prolonged. Accordingly, the endothelial cells may have a tonic inhibitory action on the coordination of islet release pulses.

Place, publisher, year, edition, pages
Springer , 2010. 215-231 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-141241DOI: 10.1007/978-90-481-3435-9_12ISBN: 9789048134359 (print)ISBN: 9789048134342 (print)OAI: oai:DiVA.org:uu-141241DiVA: diva2:385300
Available from: 2011-01-11 Created: 2011-01-11 Last updated: 2011-01-25Bibliographically approved

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