uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE: a European randomized dietary intervention study
Show others and affiliations
2011 (English)In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 35, no 6, 800-809 p.Article in journal (Refereed) Published
Abstract [en]

Background:Excessive energy intake and obesity lead to the metabolic syndrome (MetS). Dietary saturated fatty acids (SFAs) may be particularly detrimental on insulin sensitivity (SI) and on other components of the MetS.Objective:This study determined the relative efficacy of reducing dietary SFA, by isoenergetic alteration of the quality and quantity of dietary fat, on risk factors associated with MetS.Design:A free-living, single-blinded dietary intervention study.Subjects and Methods:MetS subjects (n=417) from eight European countries completed the randomized dietary intervention study with four isoenergetic diets distinct in fat quantity and quality: high-SFA; high-monounsaturated fatty acids and two low-fat, high-complex carbohydrate (LFHCC) diets, supplemented with long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) (1.2 g per day) or placebo for 12 weeks. SI estimated from an intravenous glucose tolerance test (IVGTT) was the primary outcome measure. Lipid and inflammatory markers associated with MetS were also determined.Results:In weight-stable subjects, reducing dietary SFA intake had no effect on SI, total and low-density lipoprotein cholesterol concentration, inflammation or blood pressure in the entire cohort. The LFHCC n-3 PUFA diet reduced plasma triacylglycerol (TAG) and non-esterified fatty acid concentrations (P<0.01), particularly in men.Conclusion:There was no effect of reducing SFA on SI in weight-stable obese MetS subjects. LC n-3 PUFA supplementation, in association with a low-fat diet, improved TAG-related MetS risk profiles.

Place, publisher, year, edition, pages
2011. Vol. 35, no 6, 800-809 p.
National Category
Nutrition and Dietetics
URN: urn:nbn:se:uu:diva-141348DOI: 10.1038/ijo.2010.209ISI: 000291676100006PubMedID: 20938439OAI: oai:DiVA.org:uu-141348DiVA: diva2:385459
Available from: 2011-01-11 Created: 2011-01-11 Last updated: 2015-08-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Karsltröm, BritaVessby, Bengt
By organisation
Clinical Nutrition and Metabolism
In the same journal
International Journal of Obesity
Nutrition and Dietetics

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 186 hits
ReferencesLink to record
Permanent link

Direct link