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Small-molecule biomarkers for clinical PET imaging of apoptosis.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
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2010 (English)In: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, Vol. 51, no 6, 837-40 p.Article in journal (Refereed) Published
Abstract [en]

Apoptosis is a fundamental biologic process. Molecular imaging of apoptosis in vivo may have important implications for clinical practice, assisting in early detection of disease, monitoring of disease course, assessment of treatment efficacy, or development of new therapies. Although a PET probe for clinical imaging of apoptosis would be highly desirable, this is yet an unachieved goal, mainly because of the required challenging integration of various features, including sensitive and selective detection of the apoptotic cells, clinical aspects such as favorable biodistribution and safety profiles, and compatibility with the radiochemistry and imaging routines of clinical PET centers. Several approaches are being developed to address this challenge, all based on novel small-molecule structures targeting various steps of the apoptotic cascade. This novel concept of small-molecule PET probes for apoptosis is the focus of this review.

Place, publisher, year, edition, pages
2010. Vol. 51, no 6, 837-40 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-141419DOI: 10.2967/jnumed.109.063917PubMedID: 20484422OAI: oai:DiVA.org:uu-141419DiVA: diva2:385572
Available from: 2011-01-11 Created: 2011-01-11 Last updated: 2012-03-12Bibliographically approved

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