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Unrecognized myocardial scars detected by delayed-enhanced MRI are associated with increased levels of NT-proBNP
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
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2011 (English)In: Coronary Artery Disease, ISSN 0954-6928, E-ISSN 1473-5830, Vol. 22, no 3, 158-164 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Patients with unrecognized myocardial infarction (UMI) scars detected by delayed-enhanced magnetic resonance imaging (DE-MRI) have a decreased left ventricular ejection fraction and an increased left ventricular mass. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of heart failure, and troponin I (TnI) is a marker of myocardial injury. The primary aim of this study was to investigate whether NT-proBNP plasma levels (in addition to ejection fraction) differed in patients with UMI scars compared with normal participants. The second aim was to compare whether the TnI levels differed in those two groups. METHODS: Data from the Prospective Investigation of Vasculature in Uppsala Seniors study were used. The participants who had undergone cardiac MRI were included in this study (n=248). Patients were divided into three groups depending on the existence of a myocardial infarction (MI) scar in DE-MRI and their earlier history of MI. In all the patients, a peripheral blood sample was collected and the plasma levels of NT-proBNP and TnI were determined. RESULTS: Patients with UMI had higher plasma levels of NT-proBNP (median 140.2 ng/l; 25th-75th percentiles: 79-225.5) than no-MI participants (median 94.9 ng/l; 25th-75th percentiles: 59.2-144.2; P=0.01) and lower levels than patients with recognized MI (median 310.4 ng/l; 25th-75th percentiles: 122.6-446.5; P=0.02). Plasma TnI values did not differ among the three groups. CONCLUSION: Patients with UMI scars detected by DE-MRI have increased plasma levels of NT-proBNP that is known to correlate with an increased risk of future cardiovascular adverse events.

Place, publisher, year, edition, pages
2011. Vol. 22, no 3, 158-164 p.
Keyword [en]
epidemiology, infarction, prognosis, silent, troponin I, viability
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-141510DOI: 10.1097/MCA.0b013e328342c72eISI: 000289506000006PubMedID: 21200318OAI: oai:DiVA.org:uu-141510DiVA: diva2:385713
Available from: 2011-01-12 Created: 2011-01-12 Last updated: 2017-12-11Bibliographically approved

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Themudo, Raquel EspregueiraLindahl, BertilJohansson, LarsAhlström, HåkanEbeling Barbier, CharlotteEggers, Kai M.Bjerner, Tomas

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Themudo, Raquel EspregueiraLindahl, BertilJohansson, LarsAhlström, HåkanEbeling Barbier, CharlotteEggers, Kai M.Bjerner, Tomas
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RadiologyDepartment of Medical SciencesUCR-Uppsala Clinical Research CenterClinical Chemistry
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