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Proteolytic cascades and their involvement in invertebrate immunity
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
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2010 (English)In: TIBS -Trends in Biochemical Sciences. Regular ed., ISSN 0968-0004, E-ISSN 1362-4326, Vol. 35, no 10, 575-583 p.Article, review/survey (Refereed) Published
Abstract [en]

Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following their initiation by pattern recognition proteins, control several such reactions, notably coagulation, melanisation, activation of the Toll receptor and complement-like reactions. However, there is considerable variation among invertebrates and these cascades, although widespread, are not present in all phyla. In recent years, significant progress has been made in identifying and characterizing these cascades in insects. Notably, recent work has identified several connections and shared principles among the different pathways, suggesting that cross-talk between them may be common.

Place, publisher, year, edition, pages
2010. Vol. 35, no 10, 575-583 p.
Keyword [en]
complement evolution, prophenoloxidase, coagulation, toll receptor
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Research subject
Biology with specialization in Comparative Physiology
URN: urn:nbn:se:uu:diva-141588DOI: 10.1016/j.tibs.2010.04.006ISI: 000283411100006PubMedID: 20541942OAI: oai:DiVA.org:uu-141588DiVA: diva2:385853
Available from: 2011-01-12 Created: 2011-01-12 Last updated: 2016-05-15

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Cerenius, LageSöderhäll, Kenneth
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