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Leader of the pack: gene mapping in dogs and other model organisms
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2008 (English)In: Nature reviews genetics, ISSN 1471-0056, Vol. 9, no 9, 713-725 p.Article, review/survey (Refereed) Published
Abstract [en]

The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. We share many diseases with our canine companions, including cancer, diabetes and epilepsy, making the dog an ideal model organism for comparative disease genetics. Using newly developed resources, whole-genome association in dog breeds is proving to be exceptionally powerful. Here, we review the different trait-mapping strategies, some key biological findings emerging from recent studies and the implications for human health. We also discuss the development of similar resources for other vertebrate organisms.

Place, publisher, year, edition, pages
2008. Vol. 9, no 9, 713-725 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-141962DOI: 10.1038/nrg2382ISI: 000258565200015PubMedID: 18714291OAI: oai:DiVA.org:uu-141962DiVA: diva2:386659
Available from: 2011-01-13 Created: 2011-01-13 Last updated: 2011-06-28Bibliographically approved

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Lindblad-Toh, Kerstin
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