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Network organization of interstitial connective tissue cells in the human endolymphatic duct
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2003 (English)In: Journal of Histochemistry and Cytochemistry, ISSN 0022-1554, E-ISSN 1551-5044, Vol. 51, no 11, 1491-500 p.Article in journal (Refereed) Published
Abstract [en]

The human endolymphatic duct (ED) and sac of the inner ear have been suggested to control endolymph volume and pressure. However, the physiological mechanisms for these processes remain obscure. We investigated the organization of the periductal interstitial connective tissue cells and extracellular matrix (ECM) in four freshly fixed human EDs by transmission electron microscopy and by immunohistochemistry. The unique surgical material allowed a greatly improved structural and epitopic preservation of tissue. Periductal connective tissue cells formed frequent intercellular contacts and focally occurring electron-dense contacts to ECM structures, creating a complex tissue network. The connective tissue cells also formed contacts with the basal lamina of the ED epithelium and the bone matrix, connecting the ED with the surrounding bone of the vestibular aqueduct. The interstitial connective tissue cells were non-endothelial and non-smooth muscle fibroblastoid cells. We suggest that the ED tissue network forms a functional mechanical entity that takes part in the control of inner ear fluid pressure and endolymph resorption.

Place, publisher, year, edition, pages
2003. Vol. 51, no 11, 1491-500 p.
Keyword [en]
Connective Tissue Cells/metabolism/*ultrastructure, Endolymphatic Duct/metabolism/*ultrastructure, Epithelium/metabolism/ultrastructure, Extracellular Matrix/metabolism, Humans, Immunohistochemistry, Microscopy; Electron/methods
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-10926DOI: 10.1177/002215540305101109PubMedID: 14566021OAI: oai:DiVA.org:uu-10926DiVA: diva2:38694
Available from: 2007-05-04 Created: 2007-05-04 Last updated: 2011-11-10Bibliographically approved

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Rubin, KristoferRask-Andersen, Helge
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Department of Medical Biochemistry and MicrobiologyOtolaryngology and Head and Neck Surgery
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