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Isosorbide delays gentamicin-induced vestibular sensory cell death
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
2005 (English)In: Journal for Oto-Rhino-Laryngology, ISSN 0301-1569, E-ISSN 1423-0275, Vol. 67, no 5, 276-81 p.Article in journal (Refereed) Published
Abstract [en]

The efficacy of isosorbide for protection from vestibular sensory cell damage was investigated. The effects of isosorbide on gentamicin-induced production of nitric oxide (NO) and reactive oxygen species (ROS) were studied by means of the fluorescence indicators 4,5-diaminofluorescein diacetate and dihydrotetramethylrosamine. The effect on gentamicin-induced vestibular sensory cell damage was examined by using an in vitro LIVE/DEAD system. Isosorbide inhibited the production of both NO and ROS. Isosorbide limited the vestibular sensory cell damage caused by gentamicin. It is, therefore, suggested that isosorbide may help to treat inner ear disorders.

Place, publisher, year, edition, pages
2005. Vol. 67, no 5, 276-81 p.
Keyword [en]
Animals, Anti-Bacterial Agents/*toxicity, Cell Survival/drug effects, Diuretics; Osmotic/*pharmacology, Free Radical Scavengers/*pharmacology, Gentamicins/*toxicity, Guinea Pigs, Hair Cells; Vestibular/*drug effects, Isosorbide/*pharmacology, Nitric Oxide/antagonists & inhibitors/metabolism, Reactive Oxygen Species/antagonists & inhibitors/metabolism
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-10935DOI: 10.1159/000089408PubMedID: 16374060OAI: oai:DiVA.org:uu-10935DiVA: diva2:38703
Available from: 2008-02-19 Created: 2008-02-19 Last updated: 2017-12-11Bibliographically approved

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Anniko, Matti

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