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Endoderm induction for hepatic and pancreatic differentiation of ES cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Clinical Immunology.
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2008 (English)In: Acta Medica Okayama, ISSN 0386-300X, Vol. 62, no 2, 63-68 p.Article, review/survey (Refereed) Published
Abstract [en]

Hepatic and pancreatic differentiation from ES cells is of great interest for the impact that this knowledge could have on the-treatment of hepatic and diabetic patients. The liver and pancreas initially develop by budding from the embryonic endoderm. Thus, the development of the endoderm represents an important step and has an integral common role in initiating the early stages of pancreatic and liver development. We know that the development of hepatocytes and insulin-producing pancreatic beta-cells from ES cells represents the culmination of a complex developmental program. However, there has been recent progress in directing ES cells to endoderm and early-stage hepatic and pancreatic progenitor cells. We here discuss the role of the microenvironment, transcriptional factors and cytokines, which have been recognized as important molecules during the major steps of the development of the liver and pancreas. We also present the most recent advances and efforts taken to produce definitive endoderm-committed ES cells for the further differentiation of hepatocyte-like and insulin-producing cells. Recent progress in the search for new sources of hepatocytes and beta-cells has opened up several possibilities for the future of new perspectives for future of new prophylactic and therapeutic possibilities for liver diseases and diabetes.

Place, publisher, year, edition, pages
2008. Vol. 62, no 2, 63-68 p.
Keyword [en]
embryonic stem cells (ES cells), differentiation, hepatocyte like-cells, insulin-producing cells, definitive endoderm
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-142095ISI: 000255297600001PubMedID: 18464881OAI: oai:DiVA.org:uu-142095DiVA: diva2:387050
Available from: 2011-01-13 Created: 2011-01-13 Last updated: 2011-01-13Bibliographically approved

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