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Protective effect of edaravone against the ototoxicity of Pseudomonas aeruginosa exotoxin A
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
2006 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 126, no 1, 15-19 p.Article in journal (Refereed) Published
Abstract [en]

CONCLUSION: Our findings suggest that edaravone can protect against cochlear damage caused by Pseudomonas aeruginosa exotoxin A (PaExoA). OBJECTIVE: To analyze the protective effect of a free radical scavenger, edaravone, against the ototoxicity resulting from exposure of the middle ear to PaExoA. MATERIAL AND METHODS: In nine groups of albino rats the following solutions were instilled either via the tympanic membrane into the round window niche [intratympanically (i.t.)] or intravenously (i.v.): edaravone (i.v.); edaravone (i.t.); PaExoA (i.t.) + edaravone (i.t.; simultaneously); PaExoA (i.t.) + edaravone (i.t.; 1 h after); PaExoA (i.t.) + edaravone (i.t.; 24 h after); PaExoA (i.t.) + edaravone (i.v.; simultaneously); PaExoA (i.t.) + edaravone (i.v.; 1 h after); PaExoA (i.t.) + edaravone (i.v.; 24 h after); PaExoA (i.t.) + saline (i.v.). Frequency-specific (2-20 kHz) auditory brainstem responses were measured to determine hearing thresholds before and 2, 5 and 10 days after instillation. RESULTS: PaExoA had penetrated from the middle ear into the cochlea and caused hearing loss. This impairment was blocked by intratympanic injection of edaravone when given simultaneously or 1 h after the first instillation of PaExoA, or by intravenous injection of edaravone when given simultaneously. There were significant differences in protective effect between the intratympanic and intravenous routes.

Place, publisher, year, edition, pages
2006. Vol. 126, no 1, 15-19 p.
Keyword [en]
ADP Ribose Transferases/*toxicity, Animals, Antipyrine/administration & dosage/*analogs & derivatives/therapeutic use, Audiometry; Evoked Response, Auditory Threshold/*drug effects, Bacterial Toxins/*toxicity, Ear; Middle/drug effects, Exotoxins/*toxicity, Free Radical Scavengers/administration & dosage/*therapeutic use, Hearing Loss; Sensorineural/chemically induced/*prevention & control, Injections; Intravenous, Male, Random Allocation, Rats, Rats; Sprague-Dawley, Tympanic Membrane/drug effects, Virulence Factors/*toxicity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-10938DOI: 10.1080/00016480510038563PubMedID: 16308249OAI: oai:DiVA.org:uu-10938DiVA: diva2:38706
Available from: 2008-02-20 Created: 2008-02-20 Last updated: 2017-12-11Bibliographically approved

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Anniko, Matti

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