Transient receptor potential channels in the inner ear: presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear
2005 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 125, no 9, 929-34 p.Article in journal (Refereed) Published
CONCLUSION: The results of this study indicate that transient receptor potential subfamily 1 (TRPV1) may play a functional role in sensory cell physiology and that TRPV4 may be important for fluid homeostasis in the inner ear. OBJECTIVE: To analyze the expression of TRPV1 and -4 in the normal guinea pig inner ear. MATERIAL AND METHODS: Albino guinea pigs were used. The location of TRPV1 and -4 in the inner ear, i.e. cochlea, vestibular end organs and endolymphatic sac, was investigated by means of immunohistochemistry. RESULTS: Immunohistochemistry revealed the presence of TRPV1 in the hair cells and supporting cells of the organ of Corti, in spiral ganglion cells, sensory cells of the vestibular end organs and vestibular ganglion cells. TRPV4 was found in the hair cells and supporting cells of the organ of Corti, in marginal cells of the stria vascularis, spiral ganglion cells, sensory cells, transitional cells, dark cells in the vestibular end organs, vestibular ganglion cells and epithelial cells of the endolymphatic sac.
Place, publisher, year, edition, pages
2005. Vol. 125, no 9, 929-34 p.
Animals, Ear; Inner/*chemistry, Guinea Pigs, Hair Cells/chemistry, Immunohistochemistry, Organ of Corti/chemistry, Stria Vascularis/chemistry, Transient Receptor Potential Channels/*analysis
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-10940DOI: 10.1080/00016480510038572PubMedID: 16193584OAI: oai:DiVA.org:uu-10940DiVA: diva2:38708