uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
The complex between tPA and PAI-1: risk factor for myocardial infarction as studied in the SHEEP project
Division of Social Medicine, Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
Show others and affiliations
2005 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 116, no 3, 223-232 p.Article in journal (Refereed) Published
Abstract [en]


The tPA/PAI-1 complex seems to be an important biochemical marker for myocardial reinfarction. Therefore we explored the distribution, correlation and interaction of plasma concentrations of tPA/PAI-1 complex in all available patients and matched controls in the Stockholm Heart Epidemiology Program (SHEEP).


The SHEEP study is a case control study of 2246 patients with a first myocardial infarction (MI), of which 1267 surviving patients were subjected to blood sampling about 3 months after MI and compared with a control group, matched for age, sex and living area within the Stockholm County. The study consists of 886 (591 men and 295 women) patients and 1198 (753 men and 445 women) matched controls, who were all analysed for plasma tPA/PAI-1 complex.


The plasma concentration of tPA/PAI-1 complex was significantly associated with the risk for MI, for both genders. Synergistic interactions were observed in men for the co exposure to high plasma tPA/PAI-1 complex concentrations in combination with smoking (OR=4.6) or diabetes mellitus (OR=7.9). Synergism was also seen in combination with exposure to serum hypercholesterolemia or increased levels of apolipoprotein B. An antagonistic effect of the co exposure to high tPA/PAI-1 complex and hypertension was found among men with a similar tendency among women, but an antagonistic effect of increased waist/hip ratio was only observed among the women.


Measuring the plasma concentration of tPA/PAI-1 complex might be of practical value in assessing risk of MI for both genders, especially in those who are smokers or in patients with manifest diabetes mellitus.

Place, publisher, year, edition, pages
2005. Vol. 116, no 3, 223-232 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-142247DOI: 10.1016/j.thromres.2004.12.007PubMedID: 15935831OAI: oai:DiVA.org:uu-142247DiVA: diva2:387169
Available from: 2011-01-13 Created: 2011-01-13 Last updated: 2013-12-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hallqvist, Johan
In the same journal
Thrombosis Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 116 hits
ReferencesLink to record
Permanent link

Direct link