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Progesterone withdrawal effects in the open field test can be predicted by elevated plus maze performance
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
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2006 (English)In: Hormones and Behavior, ISSN 0018-506X, E-ISSN 1095-6867, Vol. 50, no 2, 208-215 p.Article in journal (Refereed) Published
Abstract [en]

Allopregnanolone (3alpha-hydroxy-5alpha-pregnane-20-one) is a ring-A-reduced metabolite of progesterone, which is naturally producedduring the luteal phase of the menstrual cycle, during pregnancy and by stressful events. The steroid hormone inhibits neural functions throughincreased chloride ion flux through the GABAA receptor. The effects and subsequent withdrawal symptoms are similar to those caused by alcohol,benzodiazepines and barbiturates. This study examined the withdrawal effects of progesterone with regards to the influence of individual baselineexploration and risk taking. Rats were tested on the elevated plus maze (EPM) before hormonal treatment, in order to evaluate differences in risktaking and exploration of open and elevated areas. Treatment consisted of ten consecutive once a day progesterone or vehicle s.c. injections. Onthe last day of treatment, estradiol was injected in addition to progesterone, followed by a 24-h withdrawal before testing in the open field test(OF). Progesterone-treated rats showed a withdrawal effect of open area avoidance in the OF. The vehicle-treated control rats showed strongcorrelations between the EPM and OF parameters. This relationship was not found for the progesterone group at withdrawal. Rats with greaternumbers of open arm entrance in the EPM pretest showed an increased sensitivity to progesterone withdrawal (PWD) compared to rats with lowexploration and risk taking. The results indicate that the effects of PWD relate to individual exploration and risk taking. Furthermore, the possibleanalogy of PWD and PMS/PMDD in relation to individual traits is discussed.

Place, publisher, year, edition, pages
2006. Vol. 50, no 2, 208-215 p.
Keyword [en]
Allopregnanolone, Progesterone, Exploration, Risk taking, GABAA receptor, Rat, Withdrawal, Open field, Elevated plus maze
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-10953DOI: 10.1016/j.yhbeh.2006.03.002ISI: 000239179200005OAI: oai:DiVA.org:uu-10953DiVA: diva2:38721
Available from: 2007-05-07 Created: 2007-05-07 Last updated: 2011-07-06Bibliographically approved

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