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The synthesis of therapeutic locked nucleos(t)ides
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Bioorganic Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Bioorganic Chemistry.
2009 (English)In: Current opinion in drug discovery & development, ISSN 1367-6733, E-ISSN 2040-3437, Vol. 12, no 6, 876-898 p.Article, review/survey (Refereed) Published
Abstract [en]

This review highlights progress made during the past 2 to 3 years in the field of therapeutic locked nucleos(t)ides. Synthetic strategies to construct the conformationally locked nucleos(t)ides, their properties and potential therapeutic applications as antiviral compounds, and modified oligonucleotides to modulate antisense and RNAi properties are described.

Place, publisher, year, edition, pages
2009. Vol. 12, no 6, 876-898 p.
Keyword [en]
Antisense oligonucleotide, antivirus nucleoside, conformationally constrained nucleotide, cyclolization, locked nucleotide, LNA, carba-LNA, siRNA, synthesis
National Category
Natural Sciences Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-142179ISI: 000271384400011OAI: oai:DiVA.org:uu-142179DiVA: diva2:387237
Available from: 2011-01-13 Created: 2011-01-13 Last updated: 2011-01-13Bibliographically approved

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