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Mitochondrial DNA as a marker of molecular diversity: a reappraisal
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolution, Genomics and Systematics, Evolutionary Biology.
2009 (English)In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 18, no 22, 4541-4550 p.Article, review/survey (Refereed) Published
Abstract [en]

Over the last three decades, mitochondrial DNA has been the most popular marker of molecular diversity, for a combination of technical ease-of-use considerations, and supposed biological and evolutionary properties of clonality, near-neutrality and clock-like nature of its substitution rate. Reviewing recent literature on the subject, we argue that mitochondrial DNA is not always clonal, far from neutrally evolving and certainly not clock-like, questioning its relevance as a witness of recent species and population history. We critically evaluate the usage of mitochondrial DNA for species delineation and identification. Finally, we note the great potential of accumulating mtDNA data for evolutionary and functional analysis of the mitochondrial genome.

Place, publisher, year, edition, pages
2009. Vol. 18, no 22, 4541-4550 p.
Keyword [en]
adaptation, molecular clock, mutation hotspots, population, recombination, Wolbachio
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-142175DOI: 10.1111/j.1365-294X.2009.04380.xISI: 000271468800006OAI: oai:DiVA.org:uu-142175DiVA: diva2:387362
Available from: 2011-01-14 Created: 2011-01-13 Last updated: 2011-01-14Bibliographically approved

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