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Kill the messenger: bacterial antisense RNA promotes mRNA decay.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Microbiology. (Wagner)
2009 (English)In: Nature Structural & Molecular Biology, ISSN 1545-9993, E-ISSN 1545-9985, Vol. 16, no 8, 804-806 p.Article in journal (Refereed) Published
Abstract [en]

Bacterial antisense RNAs target translation initiation regions (TIR s) to compete with ribosome binding, thus repressing translation and—secondarily—causing degradation of the naked mRNA. A new study reports on an antisense RNA that directly accelerates mRNA decay by targeting a sequence deep within the coding region, far downstream of the TIR.

Place, publisher, year, edition, pages
2009. Vol. 16, no 8, 804-806 p.
National Category
Cell and Molecular Biology
URN: urn:nbn:se:uu:diva-142490DOI: 10.1038/nsmb0809-804ISI: 000268738700005PubMedID: 19654618OAI: oai:DiVA.org:uu-142490DiVA: diva2:387484
Available from: 2011-01-14 Created: 2011-01-14 Last updated: 2014-05-28Bibliographically approved

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