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Proteomics in diabetes research
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2009 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, E-ISSN 1872-8057, Vol. 297, no 1-2, 93-103 p.Article, review/survey (Refereed) Published
Abstract [en]

Both type 1 and type 2 diabetes mellitus are heterogeneous diseases with alterations in many genes and their products. Not all transcriptional alterations lead to protein changes, which makes it very important to, in conjunction with mRNA expression studies, also address changes in cellular protein levels. Various proteomic techniques are available for measuring many protein changes simultaneously. Many proteomic studies have been performed in the context of diabetes research, with the aims of both describing the healthy tissue and to unravel the complex pathophysiology behind the disease. In addition, effects on proteins induced by different treatments have also been investigated using proteomic approaches. In this paper the field of diabetes proteomics today will be reviewed. Findings from proteomic studies investigating pancreatic islets and beta-cells as well as serum, fat, skeletal muscle and liver are described.

Place, publisher, year, edition, pages
2009. Vol. 297, no 1-2, 93-103 p.
Keyword [en]
Proteomics, Diabetes, Protein profiling, Islets, Serum
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-142360DOI: 10.1016/j.mce.2008.06.018ISI: 000262600600012OAI: oai:DiVA.org:uu-142360DiVA: diva2:387507
Available from: 2011-01-14 Created: 2011-01-13 Last updated: 2011-01-14Bibliographically approved

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