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Consensus Paper of the WFSBP Task Force on Biological Markers of Dementia: The role of CSF and blood analysis in the early and differential diagnosis of dementia
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2009 (English)In: Revista de Psiquiatria Clinica, ISSN 0101-6083, Vol. 36, 1-16 p.Article, review/survey (Refereed) Published
Abstract [en]

Aging of population, and increasing life expectancy result in an increasing number of patients with dementia. This symptom can be a part of a completely curable disease of the central nervous system (e.g, neuroinflammation), or a disease currently considered irreversible (e.g, Alzheimer's disease, AD). In the latter case, several potentially successful treatment approaches are being tested now, demanding reasonable standards of pre-mortem diagnosis. Cerebrospinal fluid and serum analysis (CSF/serum analysis), whereas routinely performed in neuroinflammatory diseases, still requires standardization to be used as an aid to the clinically based diagnosis of AD. Several AD-related CSF parameters (total tau, phosphorylated forms of tau, A beta peptides, ApoE genotype, p97, etc.) tested separately or in a combination provide sensitivity and specificity in the range of 85%, the figure commonly expected from a good diagnostic tool. In this review, recently published reports regarding progress in neurochemical pre-mortem diagnosis of dementias are discussed with a focus on an early and differential diagnosis of AD. Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed.

Place, publisher, year, edition, pages
2009. Vol. 36, 1-16 p.
Keyword [en]
Dementia, Alzheimer's disease, neuroinflammation, cerebrospinal fluid
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URN: urn:nbn:se:uu:diva-142325ISI: 000264605600001OAI: oai:DiVA.org:uu-142325DiVA: diva2:387733
Available from: 2011-01-14 Created: 2011-01-13 Last updated: 2011-01-14Bibliographically approved

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