Spatio-Temporal Dynamics of Phosphatidylinositol-3,4,5-Trisphosphate Signalling
2009 (English)In: Vitamines and Hormones, ISSN 0083-6729, Vol. 80, 287-311 p.Article, review/survey (Refereed) Published
Many effects of insulin, insulin-like growth factors and other receptor stimuli are mediated via the phospholipid second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 is formed by the activity of phosphoinositide 3-kinases in the plasma membrane, where it serves to recruit signalling proteins. These proteins coordinate complex events leading to changes in cell metabolism, growth, movement and survival. Over the past decade, new techniques for measurements of PIP3 in the plasma membrane of individual living cells have markedly improved our understanding of the role of this messenger in a variety of cellular processes. This review summarises the mechanisms involved in formation and degradation of PIP3 in insulin-responsive cells, how PIP3 can be measured in individual cells as well as accumulating evidence that the plasma membrane PIP3 concentration undergoes complex spatiotemporal patterns in many types of cells, with particular emphasis on autocrine insulin-induced PIP3 oscillations in pancreatic beta-cells.
Place, publisher, year, edition, pages
2009. Vol. 80, 287-311 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-142320DOI: 10.1016/S0083-6729(08)00611-0ISI: 000264638200011OAI: oai:DiVA.org:uu-142320DiVA: diva2:387756