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Can we prevent diabetic birth defects with micronutrients?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2009 (English)In: Diabetes, obesity and metabolism, ISSN 1462-8902, E-ISSN 1463-1326, Vol. 11, no 8, 770-778 p.Article, review/survey (Refereed) Published
Abstract [en]

Congenital malformations are more common in infants of diabetic women than in children of non-diabetic women. The mechanisms behind diabetes-induced congenital anomalies are not known. Disturbed micronutrient metabolism, in concert with oxidative stress, has been suggested as a cause of diabetes-induced malformations by several studies. In experimental work, administration of inositol, arachidonic acid and several antioxidative compounds, as well as folic acid, to the embryo, has proven to attenuate the teratogenic effects of a diabetic environment. Future therapeutic efforts may include supplementation with antioxidants or micronutrients, such as folic acid, to the pregnant diabetic woman, although exact compounds and doses need to be determined.

Place, publisher, year, edition, pages
2009. Vol. 11, no 8, 770-778 p.
Keyword [en]
diabetes, pregnancy, malformation, micronutrient
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-142287DOI: 10.1111/j.1463-1326.2009.01053.xISI: 000267426100004OAI: oai:DiVA.org:uu-142287DiVA: diva2:387824
Available from: 2011-01-14 Created: 2011-01-13 Last updated: 2011-01-14Bibliographically approved

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