uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Mantle cell lymphoma: does primary intensive immunochemotherapy improve overall survival for younger patients?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Oncology.
2009 (English)In: Leukemia and Lymphoma, ISSN 1042-8194, Vol. 50, no 8, 1249-1256 p.Article, review/survey (Refereed) Published
Abstract [en]

MCL is a rare entity of non-Hodgkin lymphoma, hitherto considered incurable. There is no standard therapy, but the current treatment results do seem to have led to a prolongation of the median survival from 3 to 5 years. Following CHOP-like induction, high-dose radiochemotherapy, and autologous stem cell transplantation (ASCT) chemotherapy has been shown in a controlled trial to be superior in younger patients, but does not, however, lead to long-term freedom from disease. Results of recent prospective but uncontrolled trials of more intensive frontline immunochemotherapy containing cytarabine and rituximab followed by ASCT, however, now for the first time indicate plateaus of the curves of event-free, progression-free and overall survival, suggesting cure, but more studies and longer follow-up is needed. Following relapse, autologous stem-cell transplantation does not seem to be of value, but graft-versus-lymphoma effect has been documented, and allogeneic stem cell transplantation with reduced-intensity conditioning is emerging as the treatment of choice in this setting.

Place, publisher, year, edition, pages
2009. Vol. 50, no 8, 1249-1256 p.
Keyword [en]
Mantle cell lymphoma, immunochemotherapy, autologous stem-cell transplantation
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-142265DOI: 10.1080/10428190903040030ISI: 000268825900003OAI: oai:DiVA.org:uu-142265DiVA: diva2:387853
Available from: 2011-01-15 Created: 2011-01-13 Last updated: 2011-01-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
In the same journal
Leukemia and Lymphoma
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 134 hits
ReferencesLink to record
Permanent link

Direct link