uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening
Show others and affiliations
2006 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 45, no 5, 536-543 p.Article in journal (Refereed) Published
Abstract [en]

We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1,046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contralateral breast cancer, distant metastasis and death. After a median follow-up of 5.2 years (range 0.1-13.8) there were 44 recurrences in the RT group corresponding to a cumulative incidence of 0.07 (95% confidence interval (CI) 0.05-0.10). In the control group there were 117 recurrences giving a cumulative incidence of 0.22 (95% CI 0.18-0.26) giving an overall hazard ratio of 0.33 (95% CI 0.24-0.47, p < 0.0001). Twenty two percent of the patients had microscopically unknown or involved margins. We found no evidence for different effects of RT on the relative risk of invasive or in situ recurrence. Secondary endpoints did not differ. Women undergoing sector resection for DCIS under conditions of population based screening mammography benefit from postoperative RT to the breast. Seven patients needed RT-treatment to prevent one recurrence.

Place, publisher, year, edition, pages
2006. Vol. 45, no 5, 536-543 p.
Keyword [en]
Breast Neoplasms/diagnosis/radiotherapy/surgery, Carcinoma in Situ/diagnosis/radiotherapy/surgery, Disease-Free Survival, Female, Follow-Up Studies, Humans, Mammography/*methods, Mass Screening/*methods, Middle Aged, Predictive Value of Tests, Radiotherapy; Adjuvant, Recurrence, Sensitivity and Specificity, Survival Analysis, Sweden, Treatment Outcome
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11038DOI: 10.1080/02841860600681569PubMedID: 16864166OAI: oai:DiVA.org:uu-11038DiVA: diva2:38806
Available from: 2008-06-27 Created: 2008-06-27 Last updated: 2011-11-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Holmberg, Lars
By organisation
Department of PathologyEndocrine Surgery
In the same journal
Acta Oncologica
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 196 hits
ReferencesLink to record
Permanent link

Direct link