Oral glucose as an analgesic to reduce infant distress following immunization at the age of 3, 5 and 12 months
2007 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 96, no 2, 233-236 p.Article in journal (Refereed) Published
AIM: To evaluate oral glucose as an analgesic to reduce infant distress after immunization during the first year of life and to investigate if these effects change during this period. METHODS: A prospective controlled trial of the effectiveness of glucose on crying response to immunizations at 3, 5 and 12 months of age. A total of 110 infants were randomized to receive 2 mL of 30% glucose or water. The same solution was given at 3, 5 and 12 months. Crying was registered from onset of the injection up to 120 seconds. Infanrix Polio Hib was administered intra-muscular in the thigh. Observation nurse and parents were blind to the nature of the solution. RESULTS: Administration of glucose reduced the mean crying time by 22% at 3 months, 62% at 5 months and 52% at 12 months. The difference was significant at 5 and at 12 months. In the water group, there was a significant correlation between the children who cried at 3 months and who subsequently cried at 5 and 12 months. No correlations were found in the glucose group. CONCLUSION: Sweet solution can be used as a simple and safe method to reduce the distress following immunization in infants up to 12 months.
Place, publisher, year, edition, pages
2007. Vol. 96, no 2, 233-236 p.
Crying time, Glucose, Immunization, Infant distress
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-11094DOI: 10.1111/j.1651-2227.2007.00021.xISI: 000243993800019PubMedID: 17429911OAI: oai:DiVA.org:uu-11094DiVA: diva2:38862