uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Development of Non-Phospholipid Liposomes Containing a High Cholesterol Concentration
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry.
Show others and affiliations
2007 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 23, no 14, 7695-7699 p.Article in journal (Refereed) Published
Abstract [en]

We present a novel formulation of non-phospholipid liposomes formed from cholesterol and palmitic acid. Despite the fact that these two lipidic species do not form individually fluid bilayers, we show that once mixed together, fluid bilayers can be obtained and, moreover, these can be extruded using classical extrusion processes to form liposomes. The chem. anal. indicates that these liposomes contain 70 mol % cholesterol, a content that is considerably higher that the satn. limit generally reported for phospholipid bilayers. These cholesterol-rich liposomes, formed with mols. that have low toxicity in vivo, display an improved impermeability relative to that of traditional phospholipid liposomes. In addn., because of the presence of palmitic acid, the stability of the liposomes is pH-dependent, and it is possible to trigger the release of encapsulated materials by pH stimuli.

Place, publisher, year, edition, pages
2007. Vol. 23, no 14, 7695-7699 p.
Keyword [en]
Carboxylic acid, Saturated fatty acid, Release, pH, Stability, Toxicity, Saturation, Chemical analysis, Extrusion, Mixed bilayer, Bilayer, Fluid, Palmitic acid, Formulation, Cholesterol, Liposome, Phospholipid
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-11220DOI: 10.1021/la700824mISI: 000247487200046PubMedID: 17564471OAI: oai:DiVA.org:uu-11220DiVA: diva2:38988
Available from: 2008-01-21 Created: 2008-01-21 Last updated: 2017-12-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17564471&dopt=Citation

Authority records BETA

Karlsson, GöranEdwards, Katarina

Search in DiVA

By author/editor
Karlsson, GöranEdwards, Katarina
By organisation
Department of Physical and Analytical Chemistry
In the same journal
Langmuir
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 796 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf