uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Severe gastro-oesophageal reflux symptoms in relation to anxiety, depression and coping in a population-based study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
Show others and affiliations
2007 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 26, no 5, 683-691 p.Article in journal (Refereed) Published
Abstract [en]

Background The association between psychiatric disorders and gastro-oesophageal reflux symptoms is uncertain, and few population-based studies are available. Aim To examine the association between psychiatric and psychological factors and reflux symptoms. Methods Population-based, cross-sectional, case-control study based on two health surveys conducted in the Norwegian county Nord-Trondelag in 1984-1986 and 1995-1997. Reflux symptoms were assessed in the second survey, including 65 333 participants (70% of the county's adult population). 3153 subjects reporting severe reflux symptoms were defined as cases and 40 210 subjects without symptoms were defined as controls. Data were collected in questionnaires. Odds ratio with 95% confidence intervals were estimated using unconditional logistic regression, in adjusted models. Results Subjects reporting anxiety without depression had a 3.2-fold (95% CI: 2.7-3.8) increased risk of reflux, subjects with depression without anxiety had a 1.7-fold (95% CI: 1.4-2.1) increased risk and subjects with both anxiety and depression had a 2.8-fold (95% CI: 2.4-3.2) increased risk, compared to subjects without anxiety/depression. We observed a weak inverse association between one measure of covert coping and risk of reflux and a weak positive association between another coping measure and risk of reflux. Conclusions This population-based study indicates that anxiety and depression are strongly associated with reflux symptoms, while no consistent association regarding coping and reflux was found.

Place, publisher, year, edition, pages
2007. Vol. 26, no 5, 683-691 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-143509DOI: 10.1111/j.1365-2036.2007.03411.xISI: 000248666200006PubMedID: 17697202OAI: oai:DiVA.org:uu-143509DiVA: diva2:390302
Available from: 2011-01-21 Created: 2011-01-21 Last updated: 2011-08-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wallander, Mari-Ann
By organisation
Family Medicine and Clinical Epidemiology
In the same journal
Alimentary Pharmacology and Therapeutics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 165 hits
ReferencesLink to record
Permanent link

Direct link