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Novel cyclooxygenase-catalyzed bioactive prostaglandin F-2 alpha from physiology to new principles in inflammation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
2007 (English)In: Medicinal research reviews (Print), ISSN 0198-6325, E-ISSN 1098-1128, Vol. 27, no 4, 435-468 p.Article, review/survey (Refereed) Published
Abstract [en]

Prostaglandin F2 (PGF2), a foremost stable vasoactive cyclooxygenase (COX)-catalyzed prostaglandin, regulates a number of key physiological functions such as luteolysis, ovarian function, luteal maintenance of pregnancy, and parturition as a constitutive part of ongoing reproductive processes of the body. It has recently been implicated in the regulation of intricate pathophysiological processes, such as acute and chronic inflammation, cardiovascular and rheumatic diseases. Since the discovery of a second isoform of COXs, it has been shown that PGF2 can be formed in vivo from arachidonic acid through both isoforms of COXs, namely cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Being synthesized in various parts of the body, it metabolizes instantly to a number of rather inactive metabolites mainly in the lungs, liver, kidney, and efficiently excretes into the urine. 15-Keto-dihydro-PGF2, a major stable metabolite of PGF2 that reflects in vivo PGF2 biosynthesis, is found in larger quantities than its parent compound in the circulation and urine in basal physiological conditions, with short-lived pulses during luteolysis, induced termination of pregnancy and parturition, and is increased in tissues and various body fluids during acute, sub-chronic, and severe chronic inflammation. Further, the close relationship of PGF2 with a number of risk factors for atherosclerosis indicates its major role in inflammation pathology. This review addresses multiple aspects of PGF2 in addition to its emerging role in physiology to inflammation.

Place, publisher, year, edition, pages
2007. Vol. 27, no 4, 435-468 p.
Keyword [en]
cyclooxygenases, prostaglandins, lipid peroxidation, inflammation, diseases
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11273DOI: 10.1002/med.20098ISI: 000247408000001PubMedID: 17191216OAI: oai:DiVA.org:uu-11273DiVA: diva2:39041
Available from: 2007-08-22 Created: 2007-08-22 Last updated: 2011-03-28Bibliographically approved

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