uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
A comparison of auditory evoked potentials and spectral EEG in the ability to detect marked sevoflurane concentration alterations and clinical events
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2007 (English)In: Upsala Journal of Medical Sciences, Supplement, ISSN 0300-9726, Vol. 112, no 2, 221-229 p.Article in journal (Refereed) Published
Abstract [en]

Background. Level of consciousness monitors can distinguish between consciousness and unconsciousness during anaesthesia induction and awakening. However, this distinction is rarely a clinical problem. What we do need is a peroperative indicator signalling when the anaesthetic depth comes close to awakening, or when it is too deep. We investigated the ability of the Alaris fast extracted AEP (AAI) and the GE Healthcare Spectral Entropy algorithms State- and Response Entropy (SE/RE) to respond to marked changes in sevoflurane concentration during stable surgery and to clinical incidents. Methods. Both monitors were used simultaneously in 9 patients during sevoflurane- based anaesthesia, which at low concentrations was combined with remifentanil. Additionally, most patients had an epidural block. The response of each monitor to sevoflurane concentration alterations within 0.5-1.5 age-adjusted MAC was recorded, mainly during periods with no surgical stimulation, as was the response to stimulation during surgery and at anaesthesia induction and awakening. Off-line, the numbers of correctly detected events were calculated. Results. In total, 114 events were found. The response rate of all events (95% c.i.) was 20-37% and 40-57% for the AAI- and the Entropy- onitors, respectively, P<0.05 (Wilcoxon Matched Pair test). Conclusions. The Spectral EEG monitor performed significantly better, with a larger number of events detected, compared with the AAI-monitor. However, at the best half the number of events was detected. An anaesthetic ceiling effect might to some part explain this finding. Notwithstanding, continuous anaesthetic depth monitoring may add information to low sensitive semi-continuous standard autonomic monitoring.

Place, publisher, year, edition, pages
2007. Vol. 112, no 2, 221-229 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11304DOI: 10.3109/2000-1967-196PubMedID: 17578822OAI: oai:DiVA.org:uu-11304DiVA: diva2:39072
Available from: 2007-08-29 Created: 2007-08-29 Last updated: 2013-01-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17578822&dopt=Citation

Search in DiVA

By author/editor
Enlund, Mats
By organisation
Centre for Clinical Research, County of VästmanlandAnaesthesiology and Intensive Care
In the same journal
Upsala Journal of Medical Sciences, Supplement
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 193 hits
ReferencesLink to record
Permanent link

Direct link