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Parameters obtained by hepatobiliary scintigraphy have significant correlation with biochemical factors early after liver transplantation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
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2007 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 48, no 6, 597-604 p.Article in journal (Refereed) Published
Abstract [en]

Background: Early postoperative hepatobiliary scintigraphy after liver transplantation is performed worldwide, but data on its significance for graft function are currently limited.

Purpose: To examine the correlation between the result of early postoperative hepatobiliary scintigraphy and pre- and postoperative biochemical parameters in liver transplantation (LTx) patients.

Material and Methods: Six parameters of hepatobiliary scintigraphy using 99mTc mebrofenin were statistically analyzed in 108 LTx patients: 1) half-life of the activity of elimination of mebrofenin from the blood; 2) total clearance of mebrofenin from the blood due to all possible routes; 3) half-life of the activity due to liver uptake; 4) clearance of mebrofenin from the blood due to liver uptake; 5) time to maximal uptake in the liver; and 6) the hepatic extraction fraction (HEF) and biochemical data. Analysis between patients with preoperative normal liver function, familial amyloid polyneuropathy (FAP), and end-stage liver disease (non-FAP) was also performed.

Results: Univariate and multivariate analysis revealed that total bilirubin postoperative day 3 correlated with all three scintigraphic parameters, and peak aspartate aminotransferase and alanine aminotransferase correlated with HEF. The analysis between patients with FAP and non-FAP revealed no significant difference of scintigraphic data between the two groups.

Conclusion: A significant correlation between early postoperative scintigraphic results and biochemical parameters was demonstrated.

Place, publisher, year, edition, pages
2007. Vol. 48, no 6, 597-604 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-143630DOI: 10.1080/02841850701342120PubMedID: 17611864OAI: oai:DiVA.org:uu-143630DiVA: diva2:390783
Available from: 2011-01-24 Created: 2011-01-24 Last updated: 2011-11-29Bibliographically approved

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