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Screening of mortality in transplant patients using an assay for immune function
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
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2011 (English)In: Transplant Immunology, ISSN 0966-3274, E-ISSN 1878-5492, Vol. 24, no 4, 246-250 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: So far, the ImmuKnow Immune Cell Function Assay (Cylex, Inc., Columbia, MD, USA) has been used to assess risks of infection and rejection in transplant patients. We hypothesized that the ImmuKnow assay might be used for mortality screening in transplant patients overall. METHODS: In the period of February 2007 to December 2009, at the Uppsala University Hospital, 362 patients who received either kidney, kidney+pancreas, kidney+islet cells, liver or liver+kidney allografts were randomly screened using the ImmuKnow assay. All causes of mortality were compared between two groups: patients with at least one ImmuKnow assay below 175ng/mL and patients with all ImmuKnow assays from 175ng/mL and above. Subsequently, the frequency of rejection within thirty days of the ImmuKnow assay was compared between these two groups. RESULTS: The study included 1031 ImmuKnow assays obtained from the 362 patients. A total of 111 patients had at least one ImmuKnow below 175ng/mL and 251 patients had all their ImmuKnow assays from 175ng/mL and above. By January 31st 2010, 16 of 111 patients (14.4%) with at least one ImmuKnow assay below 175ng/mL were deceased, compared to 13 of 251 patients (5.2%) with all ImmuKnow assays from 175ng/mL and above (p=0.0053, Fisher's exact test). There was no difference in the frequency of rejection between the two groups (19.8% versus 17.5%, p=0.66). CONCLUSIONS: In addition to assessing relative risks of infection and rejection in transplant patients, the ImmuKnow assay may be used to identify patients with increased risk of short-term mortality. Transplant patients being highly overimmunosuppressed as assessed by the ImmuKnow assay do not seem to have a lower risk of short-term rejection.

Place, publisher, year, edition, pages
2011. Vol. 24, no 4, 246-250 p.
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Surgery Immunology in the medical area
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URN: urn:nbn:se:uu:diva-143631DOI: 10.1016/j.trim.2010.12.005ISI: 000291287200010PubMedID: 21232600OAI: oai:DiVA.org:uu-143631DiVA: diva2:390785
Available from: 2011-01-24 Created: 2011-01-24 Last updated: 2017-12-11Bibliographically approved

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Berglund, DavidBengtsson, MatsBiglarnia, AlirezaYamamoto, Shinjivon Zur-Mühlen, BengtLorant, TomasTufveson, Gunnar

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Berglund, DavidBengtsson, MatsBiglarnia, AlirezaYamamoto, Shinjivon Zur-Mühlen, BengtLorant, TomasTufveson, Gunnar
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Transplantation SurgeryDepartment of Oncology, Radiology and Clinical ImmunologyDepartment of Genetics and Pathology
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Transplant Immunology
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