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Schistosome-induced pathology is exacerbated and Th2 polarization is enhanced during pregnancy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
2007 (English)In: In Vivo, ISSN 0258-851X, E-ISSN 1791-7549, Vol. 21, no 4, 599-602 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate the immunopathological impact of pregnancy on an ongoing experimental schistosomiasis infection. Materials and Methods: Female BALB/c mice were randomly divided into three groups (A, B and C) of 15 animals each. The mice in Groups A and B were infected with 40 S. mansoni cercariae, percutaneously. Six weeks post-infection, the mice in Groups B and C (schistosome-naive controls) were mated. Schistosome-induced morbidity and cytokine recall responses were subsequently evaluated at weeks 7 and 8 post-infection. Results: Hepatic and pulmonary lesions resulting from trapped schistosome eggs were more frequent and more severe in Group B mice than in Group A mice. Group C mice had suppressed mitogen-stimulated interleukin 4 (IL-4) but maintained high intereferon gamma (IFN-gamma) responses. In contrast, Group A mice had elevated mitogen- and parasite-specific IL-4 but muted IFN-gamma responses. Group B mice had an early (week 7) high IL-4 response, even higher than in group A mice. Conclusion: Taken together the data suggest that pregnancy exacerbates schistosome-induced morbidity, probably through upregulation of parasite-specific IL-4.

Place, publisher, year, edition, pages
2007. Vol. 21, no 4, 599-602 p.
Keyword [en]
cytokines, morbidity, pregnancy, schistosomiasis, Th1/Th2 balance
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-143640ISI: 000248568600007PubMedID: 17708352OAI: oai:DiVA.org:uu-143640DiVA: diva2:390798
Available from: 2011-01-24 Created: 2011-01-24 Last updated: 2017-12-11Bibliographically approved

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