uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Voltage-Regulated Water Flux through Aquaporin Channels In Silico
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
2010 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 99, no 12, L97-L99 p.Article in journal (Refereed) Published
Abstract [en]

Aquaporins (AQPs) facilitate the passive flux of water across biological membranes in response to an osmotic pressure. A number of AQPs, for instance in plants and yeast, have been proposed to be regulated by phosphorylation, cation concentration, pH change, or membrane-mediated mechanical stress. Here we report an extensive set of molecular dynamics simulations of AQP1 and AQP4 subject to large membrane potentials in the range of +/- 1.5 V, suggesting that AQPs may in addition be regulated by an electrostatic potential. As the regulatory mechanism we identified the relative population of two different states of the conserved arginine in the aromatic/arginine constriction region. A positive membrane potential was found to stabilize the arginine in an up-state, which allows rapid water flux, whereas a negative potential favors a down-state, which reduces the single-channel water permeability.

Place, publisher, year, edition, pages
2010. Vol. 99, no 12, L97-L99 p.
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-143682DOI: 10.1016/j.bpj.2010.11.003ISI: 000285438900003PubMedID: 21156125OAI: oai:DiVA.org:uu-143682DiVA: diva2:390939
Available from: 2011-01-24 Created: 2011-01-24 Last updated: 2011-01-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Cell and Molecular Biology
In the same journal
Biophysical Journal
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 101 hits
ReferencesLink to record
Permanent link

Direct link