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Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2007 (English)In: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 48, no 9, 2072-2078 p.Article in journal (Refereed) Published
Abstract [en]

The Assessment of Lescol in Renal Transplantation clinical trial demonstrated the efficacy of fluvastatin in reducing cardiovascular (CV) disease in renal transplant recipients. The study included a voluntary pharmacogenetic component, enrolling 1,404 patients, which allowed association testing of baseline measures and longitudinal analysis of the 707 fluvastatin-treated and 697 placebo-treated individuals. A candidate gene approach, examining 42 polymorphisms in 18 genes, was used to test for association between selected polymorphisms and major adverse cardiac events, graft failure, change in LDL and HDL cholesterol, and baseline LDL and HDL cholesterol. Reported associations between cholesteryl ester transfer protein (CETP) and baseline HDL cholesterol were replicated, with four previously implicated single nucleotide polymorphisms significantly associated in males and one in females; tests of reported associations between CETP and CV disease yielded varying results. We found no evidence for genetic factors affecting fluvastatin response. Polymorphisms in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) previously reported to affect the efficacy of pravastatin did not show a similar effect on the reduction of LDL cholesterol by fluvastatin.

Place, publisher, year, edition, pages
2007. Vol. 48, no 9, 2072-2078 p.
Keyword [en]
pharmacogenetics, association, cholesteryl ester transfer protein, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11354DOI: 10.1194/jlr.M700076-JLR200ISI: 000248792100018PubMedID: 17563401OAI: oai:DiVA.org:uu-11354DiVA: diva2:39122
Available from: 2007-09-09 Created: 2007-09-09 Last updated: 2011-01-27Bibliographically approved

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