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Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
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2007 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 85, no 2, 497-503 p.Article in journal (Refereed) Published
Abstract [en]

Background: Vitamin A may influence gastric carcinogenesis through its essential role in controlling cell proliferation and differentiation. However, epidemiologic studies of vitamin A, retinol (preformed vitamin A), and provitamin A carotenoids in relation to the risk of gastric cancer have documented inconsistent results. Objective: The objective of the study was to examine the associations between intakes of vitamin A, retinol, and specific carotenoids and the risk of gastric cancer in a prospective population-based cohort study of Swedish adults. Design: The study cohort consisted of 82 002 Swedish adults aged 45-83 y who had completed a food-frequency questionnaire in 1997. The participants were followed through June 2005. Results: During a mean 7.2-y follow-up, 139 incident cases of gastric cancer were diagnosed. High intakes of vitamin A and retinol from foods only (dietary intake) and from foods and supplements combined (total intake) and of dietary α-carotene and β-carotene were associated with a lower risk of gastric cancer. The multivariate relative risks for the highest versus lowest quartiles of intake were 0.53 (95% CI: 0.32,0.89; P for trend = 0.02) for total vitamin A, 0.56 (95% CI: 0.33, 0.95; P for trend = 0.05) for total retinol, 0.50 (95% CI: 0.30,0.83; P for trend = 0.03) for a-carotene, and 0.55 (95% CI: 0.32, 0.94; P for trend = 0.07) for β-carotene. No significant associations were found for β-cryptoxanthin, lutein and zeaxanthin, or lycopene intake. Conclusion: High intakes of vitamin A, retinol, and provitamin A carotenoids may reduce the risk of gastric cancer.

Place, publisher, year, edition, pages
2007. Vol. 85, no 2, 497-503 p.
Keyword [en]
Malignant tumor, Gastric disease, Digestive diseases, Vitamin, Stomach cancer, Human, Cohort study, Risk factor, Carotenoid, Retinol
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11380ISI: 000244290200025PubMedID: 17284749OAI: oai:DiVA.org:uu-11380DiVA: diva2:39149
Available from: 2007-09-11 Created: 2007-09-11 Last updated: 2011-04-07Bibliographically approved

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Bergkvist, Leif
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