The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption
2007 (English)In: Addiction, ISSN 0965-2140, E-ISSN 1360-0443, Vol. 102, no 3, 389-398 p.Article in journal (Refereed) Published
AIM: To investigate possible interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among male adolescents. DESIGN, SETTING AND PARTICIPANTS: A cross-sectional study of a randomized sample of 66 male individuals from a total population of 16- and 19-year adolescents from a Swedish county. Boys, who volunteered to participate answering an alcohol-related problem/behaviour questionnaire, were investigated with regard to interactions between such problems, family function, maltreatment and MAO-A genotype. MEASUREMENTS: MAO-A genotype, family relations history, history of being maltreated or abused and alcohol-related problem behaviour. FINDINGS: Boys with the short (three-repeat) variant of the MAO-A gene, who had been maltreated/abused or came from families with poor relations, showed significantly higher scores of alcohol-related problems. We also found that maltreatment/abuse independently showed the strongest relation to alcohol-related problems among boys in our model. CONCLUSIONS: The results suggest that both maltreatment and MAO-A genotype may be useful for the understanding of male adolescent alcohol-related problem behaviour.
Place, publisher, year, edition, pages
2007. Vol. 102, no 3, 389-398 p.
Adolescent, Alcohol drinking, Behaviour, Environment, Genes, Juvenile delinquency, Risk-taking
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-11381DOI: 10.1111/j.1360-0443.2006.01702.xISI: 000244098000010PubMedID: 17298646OAI: oai:DiVA.org:uu-11381DiVA: diva2:39150