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The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Centre for Clinical Research, County of Västmanland.
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2007 (English)In: Addiction, ISSN 0965-2140, E-ISSN 1360-0443, Vol. 102, no 3, 389-398 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate possible interactions between a polymorphism in the monoamine oxidase A (MAO-A) gene promoter, family relations and maltreatment/sexual abuse on adolescent alcohol-related problem behaviour among male adolescents. DESIGN, SETTING AND PARTICIPANTS: A cross-sectional study of a randomized sample of 66 male individuals from a total population of 16- and 19-year adolescents from a Swedish county. Boys, who volunteered to participate answering an alcohol-related problem/behaviour questionnaire, were investigated with regard to interactions between such problems, family function, maltreatment and MAO-A genotype. MEASUREMENTS: MAO-A genotype, family relations history, history of being maltreated or abused and alcohol-related problem behaviour. FINDINGS: Boys with the short (three-repeat) variant of the MAO-A gene, who had been maltreated/abused or came from families with poor relations, showed significantly higher scores of alcohol-related problems. We also found that maltreatment/abuse independently showed the strongest relation to alcohol-related problems among boys in our model. CONCLUSIONS: The results suggest that both maltreatment and MAO-A genotype may be useful for the understanding of male adolescent alcohol-related problem behaviour.

Place, publisher, year, edition, pages
2007. Vol. 102, no 3, 389-398 p.
Keyword [en]
Adolescent, Alcohol drinking, Behaviour, Environment, Genes, Juvenile delinquency, Risk-taking
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-11381DOI: 10.1111/j.1360-0443.2006.01702.xISI: 000244098000010PubMedID: 17298646OAI: oai:DiVA.org:uu-11381DiVA: diva2:39150
Available from: 2008-04-01 Created: 2008-04-01 Last updated: 2017-12-11Bibliographically approved

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Lindström, LeifOreland, Lars

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