Monoamine oxidases: activities, genotypes and the shaping of behaviour
2007 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 114, no 6, 817-822 p.Article in journal (Refereed) Published
The importance of an interaction between environment and biological factors for the expression for a particular behaviour is illustrated by results from a series of adolescents in which effects of platelet MAO activity and psychosocial environment on criminality was investigated. In a favourable environment platelet MAO-B activity was not associated with criminality, while a very strong association was found in adolescents from a bad psychosocial environment. Essentially similar findings were obtained when a MAO-A promoter polymorphism was analysed instead of platelet MAO-B activity. In boys, presence of the low functioning allele seemed to be protective against criminal activity in combination with a good environment, while it predisposed for criminality in a bad psycho-social environment. In girls, instead, homozygosity for the high activity MAO-A allele interacted with environment to predict criminality. Possible mechanisms underlying the role of monoamine oxidases for behaviour are discussed.
Place, publisher, year, edition, pages
2007. Vol. 114, no 6, 817-822 p.
Monoamine oxidase, genotype, personality, behaviour, platelet
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-11434DOI: 10.1007/s00702-007-0694-8ISI: 000246735100025PubMedID: 17426915OAI: oai:DiVA.org:uu-11434DiVA: diva2:39203