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Smoking and environmental iodine as risk factors for thyroiditis among parous women
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2007 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 22, no 7, 467-472 p.Article in journal (Refereed) Published
Abstract [en]

Objective To elucidate whether exposure to some environmental factors, i.e. cigarette smoking and iodine deficiency influence the risk of thyroiditis. Methods We identified a cohort of 874, 507 parous women with self-reported information on smoking during pregnancy registered in the Swedish Medical Birth Registry from September 1983 through December 1997. Hospital diagnoses of thyroiditis (n = 286) and hypothyroidism (n = 690) following entry into the cohort were identified by record-linkage with the national Inpatient Registry. The hazard ratio (HR) of smokers compared to non-smokers and the corresponding 95% confidence limits (CL) were estimated by Cox regression. Results Smoking was inversely associated with risk of overt thyroiditis (adjusted HR = 0.72; CL = 0.54-0.95), even when diagnoses of primary hypothyroidism were included. However, a diagnosis of thyroiditis within 6 months from a childbirth was positively associated with smoking (adjusted HR = 1.88; CL = 0.94-3.76). Being born in areas of endemic goiter was not associated to hospital admission for thyroiditis. Thyroiditis patients who were smokers had more often than non-smokers a co-morbidity with other autoimmune disorders. Conclusions Smoking may increase the risk of thyroiditis occurring in the post-partum period and influence the clinical expression of other thyroiditis, especially when occurring as part of a polymorphic autoimmune disease.

Place, publisher, year, edition, pages
2007. Vol. 22, no 7, 467-472 p.
Keyword [en]
thyroiditis, hypothyroidism, cigarette smoking, iodine deficiency, cohort study, Sweden
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-144113DOI: 10.1007/s10654-007-9142-1ISI: 000248762700007PubMedID: 17557139OAI: oai:DiVA.org:uu-144113DiVA: diva2:392552
Available from: 2011-01-27 Created: 2011-01-27 Last updated: 2011-01-27Bibliographically approved

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