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Bone morphogenetic proteins and their receptors
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Uppsala University.
2006 (English)In: Encyclopedia of Life Sciences, Chichester: John Wiley & Sons, Ltd. , 2006Chapter in book (Refereed)
Abstract [en]

Bone morphogenetic proteins (BMPs) are important cell–cell signalling molecules that were first identified by their ability to induce cartilage and bone, and subsequently were shown to be multifunctional proteins. BMPs transmit their signals from membrane to nucleus through distinct combinations of type I and type II serine/threonine kinase receptors and their intracellular effectors known as Smad proteins. Transcription of target genes is regulated in a complex manner in which interactions with other signalling components and pathways define the final response.

Place, publisher, year, edition, pages
Chichester: John Wiley & Sons, Ltd. , 2006.
Keyword [en]
Bone morphogenetic protein; serine/threonine kinase receptor; signal transduction; Smad; transforming growth factor β
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11590DOI: 10.1038/npg.els.0004197ISBN: 9780470015902OAI: oai:DiVA.org:uu-11590DiVA: diva2:39359
Available from: 2007-10-04 Created: 2007-10-04 Last updated: 2011-03-01Bibliographically approved

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Heldin, Carl-Henrikten Dijke, Peter
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