uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Eczema, atopy and allergen exposure in adults: a population-based study
Show others and affiliations
2007 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 37, no 4, 526-535 p.Article in journal (Refereed) Published
Abstract [en]

Background: There are few published studies on geographical variation in prevalence of eczema in adults or its association with recognised risk factors for allergic disease. Objective: To describe the geographical variation in prevalence of eczema in adults, assess the associations with sociodemographic risk factors, serum-specific IgE and IgG, and exposure to allergen. Methods: A community-based sample of 8206 adults aged 27-56 years, in 25 European centres and Portland, USA, provided questionnaire information on symptoms of eczema. Serum-specific IgE to house dust mite (HDM), cat, grass and Cladosporium, and IgG and IgG4 to HDM and cat were measured. Mattress levels of mite and cat allergen were assessed. Results: Overall prevalence of eczema was 7.1% (range between countries of 2.2-17.6%). Eczema was associated with female gender [odds ratio (OR) 1.25; 95% confidence interval (CI) (1.01-1.55)], family history of atopic disease (OR 1.43; 95% CI 1.18-1.74), IgE sensitization to at least one allergen (OR 1.50; 95% CI 1.19-1.90), particularly Cladosporium (OR 3.65; 95% CI 1.81-7.37), and total IgE. Eczema was negatively associated with age and no clear associations were observed with sibship size, mattress mite and cat allergen levels or with cat and HDM-specific IgG or IgG4. Conclusions: There is geographical variation in the prevalence of eczema in adults both within and between countries. Although the disease is associated with IgE sensitization, in this study it was not related to mattress mite or cat allergen levels.

Place, publisher, year, edition, pages
2007. Vol. 37, no 4, 526-535 p.
Keyword [en]
Atopic dermatitis, ECRHS, Eczema, Epidemiology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11658DOI: 10.1111/j.1365-2222.2007.02679.xISI: 000245395600009PubMedID: 17430349OAI: oai:DiVA.org:uu-11658DiVA: diva2:39427
Available from: 2008-05-31 Created: 2008-05-31 Last updated: 2011-02-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Norbäck, DanJanson, Christer
By organisation
Occupational and Environmental MedicineRespiratory Medicine and Allergology
In the same journal
Clinical and Experimental Allergy
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 156 hits
ReferencesLink to record
Permanent link

Direct link