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Disease-modifying trials in Alzheimer's disease: a European task force consensus.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
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2007 (English)In: Lancet Neurology, ISSN 1474-4422, E-ISSN 1474-4465, Vol. 6, no 1, 56-62 p.Article, review/survey (Refereed) Published
Abstract [en]

After symptomatic treatments, the new target for therapeutic approaches in Alzheimer's disease is the development of disease-modifying drugs. The concept of disease modification in Alzheimer's disease is controversial and the design of these trials raises many questions. Which populations should be studied? For how long? With which principal and secondary endpoints? Are surrogate markers available? Here, we present a European consensus on disease-modifying trials in Alzheimer's disease, agreed under the auspices of the European Alzheimer's Disease Consortium and based on the European perspective of the concept of disease modification, study designs, the role for biomarkers, risk benefit, and pharmacoeconomic issues.

Place, publisher, year, edition, pages
2007. Vol. 6, no 1, 56-62 p.
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-144789DOI: 10.1016/S1474-4422(06)70677-9PubMedID: 17166802OAI: oai:DiVA.org:uu-144789DiVA: diva2:394434
Available from: 2011-02-02 Created: 2011-02-02 Last updated: 2011-10-07Bibliographically approved

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