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HPV type-specific risks of high-grade CIN during 4 years of follow-up: A population-based prospective study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
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2007 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 97, no 1, 129-132 p.Article in journal (Refereed) Published
Abstract [en]

We followed a population-based cohort of 5696 women, 32 - 38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2 + development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2 + cases, respectively. Women infected with HPV 18, 35, 39, 45, 51, 52, 56, 58, 59 and 66 had significantly lower risks of CIN2 + than women infected with HPV 16. After adjustment for infection with other HPV types, HPV types 35, 45, 59 and 66 had no detectable association with CIN2 +. In summary, the different HPV types found in cervical cancer show distinctly different CIN2 + risks, with high risks being restricted to HPV 16 and its close relatives HPV 31 and HPV 33.

Place, publisher, year, edition, pages
2007. Vol. 97, no 1, 129-132 p.
Keyword [en]
cervical cancer, screening, papillomavirus, attributable proportion, cohort studies
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-144728DOI: 10.1038/sj.bjc.6603843ISI: 000247597200020OAI: oai:DiVA.org:uu-144728DiVA: diva2:394696
Available from: 2011-02-03 Created: 2011-02-02 Last updated: 2011-02-03Bibliographically approved

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