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TGFβ signalling: a complex web in cancer progression
1.Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Japan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2010 (English)In: Nature Reviews. Cancer, ISSN 1474-175X, Vol. 10, no 6, 415-424 p.Article in journal (Refereed) Published
Abstract [en]

The distortion of growth factor signalling is the most important prerequisite in tumour progression. Transforming growth factor-beta (TGFbeta) signalling regulates tumour progression by a tumour cell-autonomous mechanism or through tumour-stroma interaction, and has either a tumour-suppressing or tumour-promoting function depending on cellular context. Such inherent complexity of TGFbeta signalling results in arduous, but promising, assignments for developing therapeutic strategies against malignant tumours. As numerous cellular context-dependent factors tightly maintain the balance of TGFbeta signalling and contribute to the regulation of TGFbeta-induced cell responses, in this Review we discuss how they maintain the balance of TGFbeta signalling and how their collapse leads to tumour progression.

Place, publisher, year, edition, pages
Macmillan Publishers Limited. , 2010. Vol. 10, no 6, 415-424 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-144970DOI: 10.1038/nrc2853PubMedID: 20495575OAI: oai:DiVA.org:uu-144970DiVA: diva2:395109
Available from: 2011-02-04 Created: 2011-02-04 Last updated: 2011-10-06Bibliographically approved

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