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Bone morphogenetic protein receptors and signal transduction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
2010 (English)In: Journal of Biochemistry (Tokyo), ISSN 0021-924X, E-ISSN 1756-2651, Vol. 147, no 1, 35-51 p.Article in journal (Refereed) Published
Abstract [en]

Bone morphogenetic proteins (BMPs) exhibit broad spectra of biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. BMPs are members of the transforming growth factor-beta (TGF-beta) family that bind to type II and type I serine-threonine kinase receptors, and transduce signals through Smad and non-Smad signalling pathways. Recent findings have revealed that BMP signalling is finely tuned by various mechanisms in both positive and negative fashions. Perturbations of BMP signalling pathways are linked to a wide variety of clinical disorders, including vascular diseases, skeletal diseases and cancer. Administration of recombinant BMP ligands and increasing endogenous expression of BMPs provide therapeutic effects on some diseases. The recent development of BMP receptor inhibitors may also prove useful for some clinical diseases induced by hyperactivation of the BMP signalling pathways.

Place, publisher, year, edition, pages
Oxford University Press on behalf of the Japanese Biochemical Society , 2010. Vol. 147, no 1, 35-51 p.
Keyword [en]
BMP, GDF, serine-threonine kinase, Smad, TGF-β
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-144978DOI: 10.1093/jb/mvp148PubMedID: 19762341OAI: oai:DiVA.org:uu-144978DiVA: diva2:395127
Available from: 2011-02-04 Created: 2011-02-04 Last updated: 2011-10-06Bibliographically approved

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