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Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value
Department of Obstetrics and Gynecology, Institute for Clinical Science and Technology, CLINTEC, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm SE-14186, Sweden.
Unit of Cancer Proteomics, Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm SE-171 76, Sweden.
Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm SE-171 76, Sweden.
Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm SE-171 76, Sweden.
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2011 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 104, no 1, 110-119 p.Article in journal (Refereed) Published
Abstract [en]

Background:Cytology-based diagnostics of squamous cervical cancer (SCC) precursor lesions is subjective and can be improved by objective markers.Methods:IHC-based analysis of ANXA6, HSP27, peroxiredoxin 2 (PRDX2), NCF2, and tropomyosin 4 (TPM4) during SCC carcinogenesis.Results:Expression of ANXA6, HSP27, PRDX2, and NCF2 in the cytoplasm of dysplastic cells increased from cervical intraepithelial neoplasia 2/3 (CIN2/3) to microinvasive cancer. Invasive SCC showed lower expression of TPM4 than CIN and normal epithelium. CIN2/3 with the highest sensitivity and specificity differed from normal epithelium by cytoplasmic expression of HSP27. Patients with cytoplasmic HSP27 expression in SCC deviating from that observed in normal epithelium had worse relapse-free (P0.019) and overall (P0.014) survival. Invasive SCC with the highest sensitivity and specificity differed from normal epithelium by expression of PRDX2 and TPM4 in the cytoplasm, from CIN2/3 by the expression of ANXA6 and TPM4 in the cytoplasm, and from microinvasive SCC by the expression of PRDX2 and ANXA6 in the cytoplasm. The number of sporadic ANXA6 cells between the atypical cells increased from CIN2/3 to invasive SCC.Conclusion:Detection of expression changes of the proteins ANXA6, HSP27, PRDX2, NCF2, and TPM4 in SCC precursor lesions may aid current cytological and pathological diagnostics and evaluation of prognosis.

Place, publisher, year, edition, pages
2011. Vol. 104, no 1, 110-119 p.
Keyword [en]
cervical cancer precursors, diagnostics, immunohistochemistry, marker protein patterns, squamous cervical cancer
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-145013DOI: 10.1038/sj.bjc.6605992ISI: 000285915900017PubMedID: 21119665OAI: oai:DiVA.org:uu-145013DiVA: diva2:395179
Available from: 2011-02-04 Created: 2011-02-04 Last updated: 2017-12-11Bibliographically approved

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