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Bovine (Bos taurus) humoral immune response against Echinococcus granulosus and hydatid cyst infertility
Escuela de Medicina Veterinaria, Facultad de Ecologı´a y Recursos Naturales, Universidad Andres Bello, Santiago, Chile.
Programa Disciplinario de Biologı´a Celular y Molecular, Instituto de Ciencias Biome´dicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Programa Disciplinario de Biologı´a Celular y Molecular, Instituto de Ciencias Biome´dicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Escuela de Medicina Veterinaria, Facultad de Ecologı´a y Recursos Naturales, Universidad Andres Bello, Santiago, Chile.
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2011 (English)In: Journal of Cellular Biochemistry, ISSN 0730-2312, E-ISSN 1097-4644, Vol. 112, no 1, 189-199 p.Article in journal (Refereed) Published
Abstract [en]

Echinococcus granulosus, the agent of hydatid disease, presents an indirect life cycle, with canines (mainly dogs) as definitive hosts, and herbivores and human as intermediary ones. In intermediary hosts fertile and infertile cysts develop, but only the first ones develop protoscoleces, the parasite form infective to definitive hosts. We report the presence of bovine IgGs in the germinal layer from infertile cysts (GLIC), in an order of magnitude greater than in the germinal layer from fertile cysts (GLFC). When extracted with salt solutions, bovine IgGs from GLIC are associated with low or with high affinity (most likely corresponding to non specific and antigen specific antibodies, respectively). Specific IgGs penetrate both the cells of the germinal layer and HeLa cultured cells and recognize parasitic proteins. These results, taken together with previous ones from our laboratory, showing induction of apoptosis in the germinal layer of infertile hydatid cysts, provide the first coherent explanation of the infertility process. They also offer the possibility of identifying the parasite antigens recognized, as possible targets for immune modulation.

Place, publisher, year, edition, pages
Wiley-Liss, Inc. , 2011. Vol. 112, no 1, 189-199 p.
Keyword [en]
cyst fertility, cystic echinococcosis, echinococcus granulosus, hydatid cysts, protoscolex
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-145015DOI: 10.1002/jcb.22916ISI: 000287216200019PubMedID: 21117064OAI: oai:DiVA.org:uu-145015DiVA: diva2:395185
Available from: 2011-02-04 Created: 2011-02-04 Last updated: 2017-12-11Bibliographically approved

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