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Toxin production by and adhesive properties of Clostridium difficile isolated from humans and horses with antibiotic-associated diarrhea
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
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2007 (English)In: Comparative Immunology, Microbiology & Infectious Diseases, ISSN 0147-9571, E-ISSN 1878-1667, Vol. 30, no 3, 163-174 p.Article in journal (Refereed) Published
Abstract [en]

Clostridium difficile is a common nosocomial pathogen in humans and animals that causes diarrhea and colitis following antibiotic therapy. Isolates of C. difficile obtained from faecal material from 20 human patients and 6 equine subjects with antibiotic-associated diarrhea were investigated regarding production of toxins A and B, their capacity to adhere to the human intestinal Caco-2 cell line and equine intestinal cells, and for the presence of fimbriae. The results showed that most (17/20) of the human clinical isolates produced both toxins A and B. One of the human isolates proved toxin A-negative/toxin B-positive. All (6/6) horse isolates were positive for both toxins A and B. Both the human and horse isolates possessed the capacity to adhere, to varying degree, to human and equine intestinal cells. It appeared that human isolates produced greater amounts of toxin B, and that there was a host-species dependency on ability to attach to intestinal epithelial cells. No fimbriae were found in any of the investigated isolates.

Place, publisher, year, edition, pages
2007. Vol. 30, no 3, 163-174 p.
Keyword [en]
Clostridium difficile, CDAD, toxin production, bacterial adhesion, Caco-2 cells, equine intestinal cells
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-145174DOI: 10.1016/j.cimid.2006.11.006ISI: 000245774600004PubMedID: 17239950OAI: oai:DiVA.org:uu-145174DiVA: diva2:395558
Available from: 2011-02-07 Created: 2011-02-07 Last updated: 2011-02-07Bibliographically approved

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