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Exercise alleviates Parkinsonism: clinical and laboratory evidence
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, Ulleråker, University Hospital.
2011 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 123, no 2, p. 73-84Article, review/survey (Refereed) Published
Abstract [en]

The present review examines the putative benefits for individuals afflicted with Parkinsonism, whether in the clinical setting or in the animal laboratory, accruing from different exercise regimes. The tendency for patients with Parkinson's disease (PD) to express either normal or reduced exercise capacity appears regulated by factors such as fatigue, quality-of-life and disorder severity. The associations between physical exercise and risk for PD, the effects of exercise on idiopathic Parkinsonism and quality-of-life, the effects of exercise on animal laboratory models of Parkinsonism and dopamine (DA) loss following neurotoxic insults, and the effects of exercise on the DA precursor, L-Dopa, efficacy are examined. It would appear to be case that in view of the particular responsiveness of the dopaminergic neurons to exercise, the principle of 'use it or lose' may be of special applicability among PD patients.

Place, publisher, year, edition, pages
2011. Vol. 123, no 2, p. 73-84
Keywords [en]
Parkinsonism, exercise, quality-of-life, function, dopamine
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-145231DOI: 10.1111/j.1600-0404.2010.01360.xISI: 000285874100001PubMedID: 21108623OAI: oai:DiVA.org:uu-145231DiVA, id: diva2:395668
Available from: 2011-02-07 Created: 2011-02-07 Last updated: 2017-12-11Bibliographically approved

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