uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials.
Show others and affiliations
2007 (English)In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 99, no 13, 998-1003 p.Article in journal (Refereed) Published
Abstract [en]

Disease-free survival is increasingly being used as the primary endpoint of most trials testing adjuvant treatments in cancer. Other frequently used endpoints include overall survival, recurrence-free survival, and time to recurrence. These endpoints are often defined differently in different trials in the same type of cancer, leading to a lack of comparability among trials. In this Commentary, we used adjuvant studies in colon cancer as a model to address this issue. In a systematic review of the literature, we identified 52 studies of adjuvant treatment in colon cancer published in 1997–2006 that used eight other endpoints in addition to overall survival. Both the definition of these endpoints and the starting point for measuring time to the events that constituted these endpoints varied widely. A panel of experts on clinical research on colorectal cancer then reached consensus on the definition of each endpoint. Disease-free survival—defined as the time from randomization to any event, irrespective of cause—was considered to be the most informative endpoint for assessing the effect of treatment and therefore the most relevant to clinical practice. The proposed guidelines may add to the quality and cross-comparability of future studies of adjuvant treatments for cancer.

Place, publisher, year, edition, pages
2007. Vol. 99, no 13, 998-1003 p.
Keyword [en]
Chemotherapy; Adjuvant/*methods, Clinical Trials, Colonic Neoplasms/*therapy, Disease Progression, Disease-Free Survival, Humans, Outcome Assessment (Health Care), Research Design, Survival Rate, Time Factors, Treatment Failure, Treatment Outcome
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-11836DOI: 10.1093/jnci/djm024PubMedID: 17596575OAI: oai:DiVA.org:uu-11836DiVA: diva2:39605
Available from: 2007-10-26 Created: 2007-10-26 Last updated: 2010-04-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17596575&dopt=Citation

Search in DiVA

By author/editor
Påhlman, Lars
By organisation
Colorectal Surgery
In the same journal
Journal of the National Cancer Institute
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 148 hits
ReferencesLink to record
Permanent link

Direct link